Feverfew PFE

    Feverfew PFEValued in folklore medicine as an herbal treatment for fever and headache,
    topical skin care products containing feverfew can help in reducing (or
    alleviating) the appearance of facial redness and skin irritation. Feverfew PFE delivers the highest level across a broad range of anti-oxidant and anti-irritant benefits. When applied topically, these formulations significantly reduce the appearance of redness and irritation.

    Feverfew PFE

    Clinical Studies

    Johnson & Johnson Consumer Companies, Inc., in partnership with a world recognized phytochemist, discovered and patented purification techniques that deplete parthenolide (a known sensitizer) resulting in an extract of Feverfew (PFE) with documented anti-irritant and antioxidant activity, ideal for sensitive skin.

    In laboratory testing, Feverfew PFE has been shown to effectively diminish multiple skin irritant pathways, as well as provide potent antioxidant activity.

    Feverfew Clinical Studies Chart

    References

    Baumann LS. Less-known botanical cosmeceuticals.Dermatol Ther. 2007 Sep-Oct;20(5):330-42. Review. Baumann L, Rodriguez D, Taylor SC, Wu J. Natural considerations for skin of color. Cutis. 2006 Dec;78(6 Suppl):2-19. Review.

    Southall M, Broad antioxidant activity of feverfew provides all day skin protection from oxidative stress. JAAD Volume 58, Issue 2, Supplement 2, Page AB67 (February 2008)

    Martin K, Sur R, Liebel F, Tierney N, Lyte P, Garay M, Oddos T, Athonavage M, Shapiro S, Southall M. Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression. Arch Dermatol Res. 2008; 300:69–80.

    Groenewegen WA, Knight DW, Heptinstall S. Progress in the medicinal chemistry of the herb feverfew. Prog
    Med Chem. 1992;29:217–238

    Heptinstall S. Feverfew—an ancient remedy for modern times? J R Soc Med. 1988;81:373–374
    Use of feverfew extract for regulating skin aging factors. European Patent EP1367993. Martin KM, Saliou C, inventors. Publication date May 16, 2007.

    Jain NK, Kulkarni SK. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in
    mice and rats. J Ethnopharmacol.1999; 68:251–259.

    Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol. 2001 8:759–766.

    Hausen BM, Osmundsen PE. Contact allergy to parthenolide in Tanacetum parthenium (L.) Schulz-Bip. (feverfew, Asteraceae) and cross-reactions to related sesquiterpene lactone containing Compositae species. Acta Derm Venereol.1983; 63:308–314.

    Paulsen E, Christensen LP, Andersen KE. Composite dermatitis from airborne parthenolide. Br J Dermatol. 2007; 156:510–515

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