Soy

Soy has been used in traditional Chinese medicine for thousands of years for its health and nutritional benefits. Soy is a rich source of protein, lipids, carbohydrates and vitamins, which provide moisturization and antioxidant
benefits to the skin. In its natural state, soybeans have specific, active,
non-denatured components that have documented benefits for skin. Whole soy contains not only essential fatty acids and saponins, but also a number of
small soy proteins including the serine protease inhibitors, soybean trypsin inhibitor (STI) and Bowman-Birk inhibitor (BBI) to even out skin tone, while large proteins have been found to smooth and soften the skin.

Clinical Studies

The addition of soy to facial moisturizers is a promising new approach for reducing the appearance of
UV-mediated photodamage and skin aging. Clinical studies have shown the efficacy of formulations containing Total Soy Complex in improving the clinical parameters of radiance.

References

C. Paine, E. Sharlow, F. Liebel, M. Eisinger, S. Shapiro and M. Seiberg (2001). J. Invest. Dermatol. 116(4): 587-595. An alternative approach to depigmentation by Soybean extracts via inhibition of the PAR-2 pathway.

M. Seiberg, J-C Liu, L.. Babiarz, E. Sharlow and S. Shapiro (2001). Soymilk reduces hair growth and hair follicle dimensions. Exp. Dermatol. 10: 405-13.M. T. Huang, J. G. Xie, C. B. Lin, M. Kizoulis, M. Seiberg, S. Shapiro, and A. H. Conney (2004).

Inhibitory Effect of Topical Applications of Non-denatured Soymilk on the Formation and Growth of UVB-induced Skin Tumors. Oncology Res. 14(7-8):387-397.

N Chen, R Scarpa, L Zhang, M Seiberg and C. B. Lin. Non-denatured Soy Extracts Reduce UVB-induced Skin Damage via Multiple Mechanisms (2008, in press, Photochemistry and Photobiology).

Zhao, R, Seiberg, M, and Iotsova-Stone, V. Soybean extracts induce elastin synthesis and inhibit elastase activity (Submitted)

C. Paine, L. Babiarz, E. Sharlow, F. Liebel, M. Eisinger, S. Shapiro and M. Seiberg, (2001) An alternative approach to depigmentation by Soybean extracts via inhibition of the PAR-2 pathway. Proceedings of the 10th European Academy of Dermatology and Venerology.

M. Seiberg, L. Babiarz, J.C. Liu, and S.S. Shapiro. (2002). Soymilk Reduces Hair Growth and Follicle Dimensions. Proceedings of the 9th European Hair Research Society meeting (Invited speaker).

M. Seiberg, J.C. Liu, L. Babiarz, S.S. Shapiro, S. Ball, I-T Wu, Y. Appa. (2003). Soy extracts reduce hair growth and hair follicle dimensions. in: D. Van Neste (ed), Hair Science and Technology.

J-C Liu, J Wu and M Seiberg. Applications of total soy in skin care. Chapter 12, p.115-127. In: Baran and Maibach (eds), Textbook of Cosmetic Dermatology (, 3rd ed., 2005).

Seiberg M, Paine C, Sharlow E et al. The protease-activated receptor 2 regulates pigmentation via keratinocyte-melanocyte interactions. Exp Cell Res 2000; 254:25-32.

Seiberg M, Liu J-C, Babiarz L et al. Soymilk reduces hair growth and hair follicle dimensions. Exp Dermatol 2001;10:405-413.

Warren Wallo, Judith Nebus, James J. Leyden MD. Efficacy of a Soy Moisturizer in Photoaging: A Double-Blind, Vehicle-Controlled, 12-Week Study. Journal of Drugs in Dermatology, October 2007.

Liu J-C, Seiberg M, Miller J et al. Soy: potential applications in skin care. Poster presented at: 59th Annual Meeting of the American Academy of Dermatology; MARCH 2-7, 2001; WASHINGTON, DC.

Liu J-C, Seiberg M, Liebel F et al. Pre-clinical and clinical evaluation of total soy preparations in improving skin physical tone parameters. Poster Presented at: 60th Annual Meeting of the American Academy of Dermatology; February 22-27, 2002; New Orleans, La.

Nebus J, Costes F, Wallo W, Kurtz ES, Leyden JJ. Clinical improvements in skin tone and texture using a facial moisturizer with a combination of total soy and SPF 30 UVA/UVB protection. Poster presented at: 64th Annual Meeting of the American Academy of Dermatology; March 3-7, 2006; San Francisco, Calif.

Nebus J, Wallo W, Sher D, Kurtz ES. Clinical improvement in skin tone, texture and radiance with facial moisturizers containing total soy complex. Poster presented at: 64th Annual Meeting of the American Academy of Dermatology; March 3-7, 2006; San Francisco, Calif.

Nebus J, Wallo W, Kurtz ES at al. Clinical improvement in facial skin tone and texture with a soy and vitamin topical preparation. Poster presented at: 60th Annual Meeting of the American Academy of Dermatology; February 22-27, 2002; New Orleans, La.

Liu J-C, Wu J, Payonk G, Summer B, Kollias N. Clinical evaluation of a total soy formulation in improving appearance of skin tone in phototype VI populations. Poster presented at: 60th Annual Meeting of the American Academy of Dermatology; February 22-27, 2002; New Orleans, La.